beneficial antipsychotic effects of omega-3 fatty acids add-on therapy for the pharmacological management of patients with schizophrenia
نویسندگان
چکیده
ôbjective: ït has been shown that serum and red blood cells’ level of ômega-3 fatty acids are low in people with schizophrenia. many studies have, therefore, attempted to explore the beneficial effects of these substances in the management of schizophrenia. however, the outcomes of the previous studies have not been clear cut. the present study is an attempt to retest this hypothesis by eliminating some of the limitations of the previous studies. methods: ïn a prospective double blind placebo-controlled clinical trial, 85 inpatients with schizophrenia randomly assigned to either risperidone plus ômega-3 or risperidone plus placebo. âfter a washout period, 44 patients received 2-8 mg/day of risperidone plus placebo and 43 patients received risperidone plus 3 gr/day of ômega-3 for 6 weeks. the treatment effect was calculated by friedman, mann whitney and t test. there were no significant differences between groups in age, sex, education, duration of illness and the number of previous hospitalizations. results: there were no statistically significant differences in the scores of positive and negative syndrome scale between two groups at weeks 0, 3 and 6 and for the whole duration of the study. çonclusion: ïn our study, ômega-3 fatty acids had no superiority to placebo in reducing the positive and negative symptoms of schizophrenia. however, due to a short duration of our study, we recommend that more long term clinical trials are needed in order to develop a better understanding of the therapeutic effects of the ômega-3 fatty acids in the pharmacological management of schizophrenia.
منابع مشابه
Beneficial effects of omega-3 fatty acids: the current evidence.
H igh triglyceride (TG) levels have been recognised as an independent risk factor for coronary heart disease (CHD), while severe hypertriglyceridaemia (fasting TGs ≥500 mg/dL) significantly increases the risk of acute pancreatitis, a potentially deadly complication. Moreover, a key feature of the dyslipidaemia associated with the metabolic syndrome as well as diabetes is elevated TG levels. Fis...
متن کاملP28: The Effects of Omega-3 and 6 Fatty Acids on Hippocampus and Learning
One of the most nervous system evolution are memory and learning in humans. Learning is a skill that enhances synaptic activity in the hippocampus of prefrontal cortex. In fact, basic passive learning is communication between the conditioned and Unconditioned stimulation. Passive learning involves three steps: habit, education and remember. According to the results of investigations, the hippoc...
متن کاملBeneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia.
OBJECTIVE Abnormalities in the immune system in schizophrenia have been described. However, important findings such as high levels of activating cytokines in the CSF and signs of CNS inflammation have been controversial. The authors conducted a trial of the new selective cyclooxygenase-2 inhibitor celecoxib, an immunomodulatory drug, in schizophrenic patients to evaluate its therapeutic effects...
متن کاملتاثیر برنامه خودمدیریتی بر افسردگی، اضطراب و استرس بیماران سکته قلبی the effect of self management program on depression anxiety and stress of patients with myocardial infraction
چکیده : هدف :.این پژوهش با هدف تعیین تاثیر برنامه خودمدیریتی بر افسردگی، اضطراب و استرس بیماران سکته قلبی ا نجام شد. روش مطالعه : این پژوهش یک مطالعه تجربی دو گروهه ، قبل و بعد است که در سال 1389 در بیمارستان امام رضا (ع) کرمانشاه بر روی 60 مددجوی مبتلا به بیماری سکته قلبی ا نجام شد . نمونه ها به روش در دسترس جمع آوری و به روش بلوکهای تصادفی در دو گروه شاهد و آزمون تخصیص داده شدند . به مدت یک...
15 صفحه اولP-138: The Effects of Omega-3, 6, 9 Fatty Acids on The Quality of Bovine Chilled Semen
Background: Many studies are being conducted to improve the quality of bull sperm in storage conditions. It seems that increasing sperm membrane unsaturated fatty acids can enhance sperm quality. This study was aimed to investigate the effects of combination of omega- 3, 6, 9 fatty acids on characteristics of bovine chilled semen. Materials and Methods: Different levels of oil containing omega-...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of psychiatry and behavioral sciencesجلد ۲، شماره ۲، صفحات ۳۵-۴۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023